Genomics Division West
Genome Sciences Department
Ernest Orlando Lawrence Berkeley National Laboratory
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Jim Bristow JBristow@lbl.gov |
My lab group is focused on application of recent genomic technologies to
understand the functions of connective tissue elements of the skin and heart
during development and in disease states. Current projects include:
1) the
use of expression profiling and comparative sequence analysis to identify
functional non-coding regulatory elements responsible for co-expression of
cardiac determination genes;
2) use of expression profiling of cardiac
myocytes subjected to different hypertrophic stimuli to understand the
molecular basis of different forms of hypertrophy and mechanisms of
hypertrophy regression;
3) expression "fingerprinting" of dermal fibroblasts
to understand abnormal collagen fibrillogenesis due to disease causing
mutations in humans and gene-targeting in mice.